Pathogenesis of genital herpes simplex virus infection in mice
- 1 August 1986
- journal article
- research article
- Published by Springer Nature in Medical Microbiology and Immunology
- Vol. 175 (5) , 281-292
- https://doi.org/10.1007/bf02126049
Abstract
Experiments in the mouse model of herpes simplex virus (HSV) infection involving the intact genital mucous membranes as inoculation site yielded the following results. In untreated mice the extent of latency was correlated with the degree of peripheral virus replication. This correlation could not be observed when the course of infection was interrupted by chemotherapy, interferon, or passive immunization. Acyclovir had little effect on peripheral virus multiplication, but markedly reduced latent ganglionic infection. As acute ganglionic infection and virus concentration in the spinal nerves were already reduced, acyclovir is assumed to inhibit either virus penetration into the nerve endings or virus replication in the ganglia. Interferon apparently has an active role in the elimination of virus infected cells from the ganglia, as its effect was restricted to a reduced rate of latency and of lethality. Passive immunization with antiserum led to similar results as ACV-treatment. While lacking a pronounced effect on virus replication in the mucous membranes, specific antibody was found to influence both virus elimination from the ganglia, and conversion from productive to latent ganglionic infection. Immune lymphocytes proved to be the only agent capable of suppressing peripheral infection, thereby inhibiting the neural spread of the virus. These results suggest that the decrease in latency may result from modulations occurring at different stages in the course of infection.Keywords
This publication has 21 references indexed in Scilit:
- Pathogenesis of genital herpes simplex virus infection in miceMedical Microbiology and Immunology, 1984
- Uptake and Transport of Herpes Simplex Virus in Neurites of Rat Dorsal Root Ganglia Cells in CultureJournal of General Virology, 1984
- Effects of genetic resistance againstHerpes simplex virus in vaginally infected miceMedical Microbiology and Immunology, 1982
- Pathogenesis of Herpes Simplex Virus in B Cell-suppressed Mice: the Relative Roles of Cell-mediated and Humoral ImmunityJournal of General Virology, 1982
- Summary of a Workshop on Antiviral Agents for Genital Herpesvirus InfectionsThe Journal of Infectious Diseases, 1982
- Acute and Recurrent Herpes Simplex in Several Strains of MiceJournal of General Virology, 1981
- The influence of different modes of immunization on the experimental genital Herpes simplex virus infection of miceMedical Microbiology and Immunology, 1981
- Ocular Infection with Herpes Simplex Virus Type 1: Prevention of Acute Herpetic Encephalitis by Systemic Administration of Virus-Specific AntibodyThe Journal of Infectious Diseases, 1979
- The Interferon SystemPublished by Springer Nature ,1979
- A Comparison of the Amounts of Mouse Interferon Obtained from Different SourcesNature, 1965