Pseudoprolines as Removable Turn Inducers: Tools for the Cyclization of Small Peptides
- 12 November 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 69 (25) , 8804-8809
- https://doi.org/10.1021/jo0484732
Abstract
The cyclization of small peptides which do not incorporate turn inducers is often difficult. We have developed a method involving the use of removable turn inducers, in the form of pseudoprolines, for the cyclization of difficult peptide sequences. The pseudoprolines induce a cisoid amide bond in the peptide backbone which facilitates cyclization. They are then readily removed to yield a cyclic peptide that does not contain any turn inducers.Keywords
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