Mode of Storage of Histamine in Mast Cells

1 August 1966

journal article
research article
Published by Wiley in Acta Physiologica Scandinavica

Vol. 67 (3-4) , 455-470
https://doi.org/10.1111/j.1748-1716.1966.tb03332.x

Abstract

Histamine containing granular material was collected from water lysed peritoneal rat mast cells. The histamine was observed to be released in the presence of cations. A re‐uptake of the amine occurred on suspension of depleted granular material in histamine containing solutions. Release as well as uptake of histamine occurred rapidly at 0°C. The results are in accordance with the idea that histamine is electrostatically bound to a granular protein‐heparin complex, the release and uptake of the amine being a physical process depending on the extra‐ and intra‐granular concentration ratios of histamine and cations.

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