Mapping of 22 new ESTs around a tumor suppressor gene and a senescence gene at 6q16→q21

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Abstract
Twenty two expressed sequence tags (ESTs) have been mapped at the border of 6q16→q21 and at the proximal end of 6q21 a candidate for two tumor suppressor genes and a senescence gene. Use of a translocation and deletion hybrid panel together with a 4-Mb YAC contig allowed us to precisely define the position of the ESTs. Thirteen ESTs were placed within the 4-Mb interval at the proximal portion of 6q21 using a restriction map of the YAC contig, seven ESTs span a 2-Mb region on the 6q16→q21 border, and two are distal to the contig. Refinement of the localization of these ESTs will provide substantial assistance in identifying new genes within the region 6q16→q21.

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