Regulation der PEP‐Carboxylase des fakultativ methylotrophen Acetobacter sp. MB 58

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Abstract
Acetobacter sp. MB 58 assimilates methanol via the fructose‐1,6‐bisphosphate variant of the hexulose phosphate pathway. Glyceraldehyde‐3‐phosphate originates as net product of an assimilation loop involving the regeneration of the C1‐acceptor ribulose‐5‐phosphate and must be available for the de novo synthesis of the C1‐acceptor as well as for the oxidative glycolysis.It is made probable in a regulatory model that this is accomplished via alternating anabolic and catabolic phases which are controlled by concerted action of PEP‐carboxylase and pyruvate kinase. Whereas Ac‐CoA is a crucial effector and ä‐ketoglutarate and aspartate are inhibitors for the PEP‐carboxylase, the pyruvate kinase is assumed to be regulated by energy charge.