Clinical spectrum of the osmotic-controlled release oral delivery system (OROS), an advanced oral delivery form

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Abstract
Background: The osmotic-controlled release oral delivery system, OROS, is an advanced drug delivery technology that uses osmotic pressure as the driving force to deliver pharmacotherapy, usually once-daily, in several therapeutic areas.Objective: The purpose of this review is to discuss the evolution of OROS technology and examine the many therapeutic areas where OROS products are being used.Methods: A search of Medline and EMBASE were performed using the keywords ‘OROS’ and ‘osmotic delivery’ for the period January 1990 to June 2005. Data were also obtained from the manufacturers’ websites and associated publications.Results: OROS technology has evolved over the last 30 years, resulting in four systems: the elementary osmotic pump; the two-layer osmotic push–pull tablet; the advanced longitudinally compressed tablet multilayer formulation; and, the L-OROS system. OROS technology is employed for drug delivery in many therapeutic areas including: cardiovascular medicine, endocrinology, urology, and...

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