The Effect of 5-Iodo-2-Deoxyuridine (IDU) in Corneal Healing
- 1 April 1964
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 71 (4) , 520-527
- https://doi.org/10.1001/archopht.1964.00970010536017
Abstract
Introduction The antimetabolic activity of 5-iodo-2′-deoxyuridine (IDU) and its effectiveness in the treatment of herpetic keratitis has been reported at length,1-7the consensus being that this antimetabolite is effective in most cases of superficial herpes of the cornea. When IDU is used in therapeutic doses it does not seem to harm the normal cornea, although the possibility of inhibition of desoxyribonucleic acid (DNA) synthesis by corneal cells,8and of cellular reproduction9has been mentioned. Delamore and Prussoff believe that the mechanism of action of IDU varies in different types of cells in vitro.10For example in mammalian cells IDU can inhibit the formation of thymidine by blocking the formation of orotic and thymidillic acid, precursors of thymidine.11In the case of herpes virus, IDU can compete with each enzymatic step in the modification and incorporation of thymidine into DNA. This will cause a halt eitherKeywords
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