Norepinephrine concentration in kidneys of normotensive Wistar–Kyoto and spontaneously hypertensive rats
- 1 April 1979
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 57 (4) , 438-441
- https://doi.org/10.1139/y79-068
Abstract
Renal norepinephrine (NE) concentration was measured in normotensive Wistar–Kyoto (WKY) and spontaneously hypertensive rats (SHR) at 7, 9, 11, and 13 weeks of age. Although the weight of kidneys was similar in the two strains of rats, renal NE concentration was significantly lower in SHR at all ages (147 ± 9 to 175 ± 13 ng/g for SHR, and 216 ± 8 to 262 ± 17 ng/g for WKY rats). The difference in renal NE concentration during this time of rapidly-increasing arterial pressure in the SHR suggests that renal NE may in some way be related to the development of hypertension.This publication has 1 reference indexed in Scilit:
- Effect of renal denervation on the development of hypertension in spontaneously hypertensive ratsCanadian Journal of Physiology and Pharmacology, 1978