A STUDY OF THE MECHANISM OF HYPERTENSION FOLLOWING INTRACISTERNAL KAOLIN INJECTION IN RATS; LEUCOCYTIC REACTION AND EFFECT ON LYMPHATIC ABSORPTION

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Abstract
39 out of 85 rats were rendered hypertensive by intracisternal injections of kaolin, following the method of Heller. Observations during repeated cisternal punctures suggested the presence of an increased intracranial pressure, as proved by Heller for dogs, though no actual measurements of cerebrospinal fluid pressure were made in our rats. Studies of the cytology of the cerebrospinal fluid showed a transient leucocytosis, beginning soon or immediately after injection and subsiding in less than 5 days. The transitory nature of this response was considered evidence against a meningeal inflammatory reaction being the principal factor in maintaining the hypertension, which, so far as our evidence to date goes, has been permanent. The passage of thorotrast from the cistern to the cervical lymph nodes was demonstrated by x-ray. This passage to the lymph nodes did not occur in animals that had been made hypertensive by the intracisternal injection of kaolin, a fact which suggests that one effect of the kaolin is to interfere with lymphatic absorption.

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