Antihypertensive (2-aminoethyl)thiourea derivatives. 1
- 1 December 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (12) , 1387-1392
- https://doi.org/10.1021/jm00186a019
Abstract
Structure-acitivity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas. From this class of compounds, the 2,6-dichlorophenyl analog 2 had potent oral antihypertensive activity in 2 hypertensive rat models and the renal hypertensive dog and displayed sedative effects which had a marked species specificity.This publication has 0 references indexed in Scilit: