Nucleolysis of the Rabbit Intervertebral Disc Using Chondroitinase ABC
- 1 February 1991
- journal article
- Published by Wolters Kluwer Health in Spine
- Vol. 16 (2) , 203-208
- https://doi.org/10.1097/00007632-199116020-00020
Abstract
The nucleolytic action of chondroitinase ABC was studied by the use of rabbit lumbar intervertebral discs. The injection of one unit of enzyme results in necrosis of the nucleus pulposus. Radiologic, histologic, and biochemical changes were evident in discs studied 2 days after injection, and consistent nucleolysis was seen in those studied after 6 days. These results show that chondroitinase ABC deserves further evaluation as a possible chemonucleolytic enzyme.Keywords
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