THE PASSAGE OF SORBITOL FROM THE BLOOD INTO THE AQUEOUS HUMOR AND CEREBROSPINAL FLUID

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Abstract
A modified micromethod for detn. of sorbitol in biological fluids was developed. The fluid (blood, aqueous, or cerebrospinal fluid) is deproteinized with silicic acid and the reduction of periodate by an aliquot of the filtrate measured by back titration of the excess periodate with thiosulfate. Other reducing substances (glucose) are included in this value and must be detd. independently. Sorbitol injected into the blood stream is rapidly eliminated, rery little remaining at the end of 3 hrs. Blood sorbitol passes into the aqueous humor and cerebrospinal fluid in but relatively small amts., making this substance an excellent osmotic agent for reducing high intraocular and intra-cranial pressures. Sorbitol gives rise to a temporary increase in the blood glucose value.

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