ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12.
- 1 July 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (7) , 3099-3103
- https://doi.org/10.1073/pnas.75.7.3099
Abstract
ATP induces a conformational change in the Escherichia coli K-12 restriction enzyme that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. However, ATP hydrolysis is a requirement for DNA cleavage.Keywords
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