Neutralizing Activity of Fragments Obtained by Papain Digestion of Viral Antibody
Open Access
- 1 August 1964
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 93 (2) , 283-292
- https://doi.org/10.4049/jimmunol.93.2.283
Abstract
Summary: When pure by Ouchterlony and immunoelectrophoretic analyses, 3.5 S Fractions I and II from anti-poliovirus γ-globulin and anti-WEE virus γ-globulin neutralized their respective viruses in the metabolic inhibition test, while 3.5 S crystalline Fractions III with trace contamination of Fraction II gave minimal (with poliovirus) or no neutralization (WEE virus). Pure, 3.5 S Fractions I and II from anti-WEE virus γ-globulin did not give significant neutralization of WEE virus in the mouse, while 3.5 S Fraction III with trace contamination of Fraction II gave significant neutralization (NI ≧ 2).Keywords
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