NIPPOSTRONGYLUS-BRASILIENSIS IN RAT - IMMUNE-RESPONSE IN SERUM AND INTESTINAL SECRETIONS

  • 1 January 1976
    • journal article
    • research article
    • Vol. C127  (2) , 215-224
Abstract
The kinetics of local and serum hemagglutinins production was observed following infections of rats with N. brasiliensis. Antibodies which appeared in the gut immediately after parasite localization had occurred there 6 days following infection with 3000 larvae. Serum antibodies were detected on day 18. Parasites were still being expelled at this time from the intestine. When rats were infected with 83 larvae, which is the smallest immunizing dose, local antibodies appeared in the same manner as in the 1st experiment; serum antibodies appearing only after challenge with 3000 larvae. Local antibody activity is mainly due to IgA [immunoglobulin A]. The presence of parasites and, at the same time, of local antibodies suggests a mechanism of worm expulsion.