Tumor Size, Nuclear Morphometry, Mitotic Indices as Prognostic Factors in Axillary -Lymph-Node-Positive Breast Cancer

Abstract
The biopsy specimens from the primary tumors of 234 women with axillary-lymph-node-positive breast carcinomas (followed up for a mean of 10.9 years) were subjected to interactive morphometric analysis of nine nuclear factors. The proliferative activity of the tumors was estimated by determining two different mitotic indices. Morphometrically determined nuclear factors and mitotic indices showed a significant correlation to the histological grading (p

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