Secretion of theorgCGene Product bySalmonella entericaSerovar Typhimurium
Open Access
- 1 November 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (11) , 6680-6685
- https://doi.org/10.1128/iai.71.11.6680-6685.2003
Abstract
HilA activates the transcription of genes on Salmonella pathogenicity island 1 (SPI1), which encodes a type III secretion system (TTSS). Previous studies showed that transposon insertions in orgC, a gene located on SPI1, increase hilA expression. We characterize the orgC gene product and show that it is secreted via the SPI1 TTSS. We propose a model whereby OrgC functions as a secreted repressor of the SPI1 virulence genes.Keywords
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