MODEL PREDICTION OF PLASMA-VOLUME CHANGE INDUCED BY HEMODIALYSIS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 104  (6) , 932-938
Abstract
The change in plasma volume by hemodialysis was simulated by combining 2 models for transcapillary and transcellular fluid exchange. Model predictions of the plasma volume change were found to be in good agreement with the measured values in 5 patients who were studied during 4-h hemodialysis at a constant ultrafiltration rate of 0.5 l/h using 3 different dialysate-Na concentrations: 7% below, 7% above and equal to the predialytic serum concentration. The measurements and model predictions indicate that the decrease in plasma volume is smaller in high Na dialysis than in normal and low Na dialysis. Because model predictions were consistent with measurements, this model should be useful in clinical practice to quantitatively analyze the change in plasma volume during hemodialysis and to relate it with hypovolemic hypotension.

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