Intestinal permeability during chemotherapy for childhood tumours
- 1 February 1988
- journal article
- research article
- Published by Springer Nature in European Journal of Pediatrics
- Vol. 147 (2) , 123-127
- https://doi.org/10.1007/bf00442208
Abstract
The intestinal permeability to mannitol and lactulose was measured in 29 children receiving treatment for solid tumours. At the time of study they had no gastrointestinal symptoms and appeared clinically well. However, there was a significant reduction in the absorption of mannitol when compared to normal children. This small bowel dysfunction may result in malabsorption of nutrients and drugs. There was a significant correlation between decreased mannitol absorption and low nutritional status.Keywords
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