TRANSPLANTATION OF CULTURED THYMIC FRAGMENTS - RESULTS IN NUDE-MICE .4. EFFECT OF AMOUNT OF THYMIC TISSUE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 5  (5-6) , 407-417
Abstract
Nude mice were transplanted with varying amounts of cultured thymic fragments [CTF] equivalent to tissue derived from < 1, 1 or 3 thymuses. All amounts of tissue preserved life, restored skin graft rejection, thymus-dependent allotolerance, anti-sheep erythrocyte antibody responses and serum IgG1 levels to near normal values. Serum IgA levels, IgE and hemagglutinating responses to ovalbumin and mitogen proliferation were more dependent upon the mass of thymus transplanted. In some cases, allogeneic CTF transplantation results showed a greater mass effect, but this was apparent only when < 1 thymus equivalent was used. These data correlate well with the heterogeneity of the DiGeorge syndrome and variable results seen with human CTF transplantation.

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