Physiologic and metabolic response to progressive and prolonged exercise in amyotrophic lateral sclerosis
- 30 June 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 37 (7) , 1217
- https://doi.org/10.1212/wnl.37.7.1217
Abstract
Physical work capacity in 35 ALS patients and 6 untrained controls was evaluated during progressive bicycle ergometery. In the ALS patients, maximum oxygen consumption (VO2max) and work capacity (Wmax) drop in relation to the decrease in ALS functional score. However, the oxygen cost (ml O2/kpm) of submaximal exercise was significantly increased. Prolonged submaximal exercise tests in six ALS patients and six matched untrained controls indicated that the exercise-induced increase in plasma free fatty acids, beta-hydroxybuty-rate, esterified carnitine, and muscle esterified carnitine was significantly retarded in ALS patients.This publication has 10 references indexed in Scilit:
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