A Selected Ion Monitoring GC/MS Assay for 3,4,4'-Trichlorocarbanilide and its Metabolites in Biological Fluids
- 28 February 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 11 (2) , 75-80
- https://doi.org/10.1093/jat/11.2.75
Abstract
A selected ion monitoring gas chromatography/mass spectrometric method for the quantitative determination of 3,4,4′-trichlorocarbanilide (TCC) and its major metabolites (the 2′-hydroxy sulfate and the N- and N′-glucuronides) in human plasma and urine was developed using the deuterium-labelled compounds as internal standards. Limits of detection of 3 ng/mL in urine for the N-glucuronides and of 1.5 ng/mL in plasma for the 2′-hydroxy sulfate were attained. Use of the method was illustrated in a study in human subjects employing TCC-containing bar soaps.This publication has 4 references indexed in Scilit:
- GLC Determination of Free Triclocarban in BloodJournal of Pharmaceutical Sciences, 1977
- High-Pressure Liquid Chromatographic Studies of TCC (R) and Metabolites in Experimental Animals and ManJournal of Chromatographic Science, 1977
- IDENTIFICATION OF METABOLITES OF TRICHLOROCARBANILIDE IN RAT1977
- METABOLISM AND TOXICITY OF HALOGENATED CARBANILIDES - BILIARY METABOLITES OF 3,4,4'-TRICHLOROCARBANILIDE AND 3-TRIFLUOROMETHYL-4,4'-DICHLOROCARBANILIDE IN RAT1977