Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease
- 1 August 1990
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 28 (2) , 174-177
- https://doi.org/10.1002/ana.410280210
Abstract
Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.This publication has 14 references indexed in Scilit:
- A Study of Infantile Motor Neuron Disease with Neurofilament and Ubiquitin Immunocytochemistry*Neuropediatrics, 1989
- Immunohistochemical verification of senile and kuru plaques in Creutzfeldt‐Jakob disease and the allied diseaseAnnals of Neurology, 1988
- Amyloid scrapie plaques in mice, and Alzheimer senile plaques, share common antigens with tau, a microtubule-associated proteinNeuroscience Letters, 1987
- Phosphorylation determines two distinct species of tau in the central nervous systemCell Motility, 1987
- A COMPARATIVE STUDY OF MODIFIED BIELSCHOWSKY, BODIAN AND THIOFLAVIN S STAINS ON ALZHEIMER'S NEUROFIBRILLARY TANGLESNeuropathology and Applied Neurobiology, 1986
- Identification of prion amyloid filaments in scrapie-infected brainCell, 1985
- Antibodies to a scrapie prion proteinNature, 1984
- CREUTZFELDT-JAKOB DISEASE VIRUS ISOLATIONS FROM THE GERSTMANN-STRÄUSSLER SYNDROMEBrain, 1981
- AMYLOID PLAQUES IN THE BRAINS OF MICE INFECTED WITH SCRAPIE: MORPHOLOGICAL VARIATION AND STAINING PROPERTIESNeuropathology and Applied Neurobiology, 1975
- Kuru-Like Neuropathological Changes in a North AmericanArchives of Neurology, 1972