PRENATAL TREATMENT OF THYROTOXICOSIS TO PREVENT INTRAUTERINE GROWTH-RETARDATION

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 60  (1) , 122-124
Abstract
A woman with hypothyroidism and Graves ophthalmopathy was treated with propylthiouracil during her 2nd pregnancy. This was employed because her 1st pregnancy resulted in an infant with severe intrauterine growth retardation and neonatal thyrotoxicosis. The antithyroid drug used during the 2nd pregnancy crossed the placenta and treated the infant in utero. The infant was delivered by elective cesarean section at 36 wk and was a live-born male with appropriate height and weight without evidence of thyrotoxicosis. The therapeutic benefit of propylthiouracil during this 2nd pregnancy seems likely, based on the development of neonatal thyrotoxicosis after 4 days of life and on the presence of high thyroid-stimulating Ig levels in the mother and the infant.

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