Increased Src kinase level results in increased protein tyrosine phosphorylation in scrapie‐infected neuronal cell lines
Open Access
- 21 April 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (11) , 2603-2608
- https://doi.org/10.1016/j.febslet.2006.03.092
Abstract
In addition, an important increase in the protein tyrosine phosphorylation signal was observed in ScGT1 and ScN2a cells, which was further shown to be Src‐dependent, as treatment with PP2 – a Src family kinase specific inhibitor, reversed the protein tyrosine phosphorylation profile. Abnormal Src‐kinase activation and subsequent protein tyrosine phosphorylation may be key elements in the neuropathology of the prion diseases.Keywords
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