The effect of apomorphine on regional cerebral blood flow in schizophrenia
- 1 November 1989
- journal article
- clinical trial
- Published by American Psychiatric Association Publishing in The Journal of Neuropsychiatry and Clinical Neurosciences
- Vol. 1 (4) , 377-384
- https://doi.org/10.1176/jnp.1.4.377
Abstract
A double-blind, placebo-controlled crossover study of the effects of apomorphine on regional cerebral blood flow (rCBF) during a prefrontal cortex activation task was undertaken to explore the role of dopamine on cortical function. The subjects were eight drug-free, chronically psychotic patients; six patients had schizophrenia. In each, apomorphine increased the relative prefrontal flow. The results suggest that enhanced prefrontal dopamine activity may reverse deficits in prefrontal cortex metabolism in schizophrenia.Keywords
This publication has 37 references indexed in Scilit:
- Physiological Dysfunction of Dorsolateral Prefrontal Cortex in SchizophreniaArchives of General Psychiatry, 1988
- Implications of Normal Brain Development for the Pathogenesis of SchizophreniaArchives of General Psychiatry, 1987
- Effects of amphetamine on local cerebral metabolism in normal and schizophrenic subjects as determined by positron emission tomographyPsychopharmacology, 1987
- Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in SchizophreniaArchives of General Psychiatry, 1986
- Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in SchizophreniaArchives of General Psychiatry, 1986
- Regional cerebral blood flow in a case of amphetamine intoxicationPsychopharmacology, 1980
- Correlation Between Regional Cerebral Blood Flow and Oxidative MetabolismArchives of Neurology, 1976
- Mode of action of apomorphine and dexamphetamine on gnawing compulsion in ratsPsychopharmacology, 1967
- Effects of Different Brain Lesions on Card SortingArchives of Neurology, 1963
- Influence of amphetamine sulfate on cerebral metabolism and blood flow in man*, ††This work was supported, in part, by a grant-in-aid from the National Institute of Health, U. S. Public Health Service.Journal of the American Pharmaceutical Association (Scientific ed.), 1949