Inhibitory action of 2-(1-,2-benzisoxazol-3-yl)-3-(2-(2-piperidinoethoxy)phenyl)acrylonitrile (SX-284) on acetylcholine release from vagus nerve in guinea pig ileum.

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Abstract
Newly synthesized compound, 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy)phenyl]acrylonitrile (SX-284) inhibited electrically evoked acetylcholine release from the stores in the myenteric plexus-longitudinal strips of guinea pig ileum which was labelled with [3H]-choline but not the evoked release of tracer from rat vas deferens after labelling with [3H]-norepinephrine. These results support our previous findings that SX-284 specifically inhibit acetylcholine release from the vagus nerve in the gastrointestinal canal.

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