Actions of the novel bronchodilator, trimetaquinol, on bovine pulmonary vein
- 1 January 1980
- journal article
- letter
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 58 (1) , 101-103
- https://doi.org/10.1139/y80-018
Abstract
The actions of the β-sympathomimetic bronchodilator trimetaquinol (TMQ) were examined on bovine pulmonary vein smooth muscle in vitro. TMQ partially and reversibly inhibited 5-hydroxytryptamine (5HT) induced contractions of the vein strips. The relaxant activity was neither blocked by propranolol (10−7 M) nor enhanced by phentolamine (10−7 M). Isoproterenol, alone or in the presence of phentolamine (10−7 M), was much less effective than TMQ in relaxing 5HT-induced contractions. From these results it is suggested that TMQ functions via a "non-β-adrenergic" mechanism to relax bovine pulmonary vein smooth muscle.This publication has 0 references indexed in Scilit: