Comparison of the effects of morphine, pethidine and pentazocine in rabbits pretreated with a monoamine oxidase inhibitor

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Abstract
1 Rabbits were premedicated with pargyline and the changes in rectal temperature measured after the intravenous infusion of morphine, pentazocine and pethidine. 2 Pethidine produced pronounced rises in rectal temperature which were dose dependent. One out of the four rabbits given 1 mg/kg died in hyperthermia. Four out of the four rabbits given 5 mg/kg died in hyperthermia. Doses of 10 mg/kg of pethidine caused no significant change in the rectal temperature of rabbits not pretreated with pargyline. 3 Morphine and pentazocine in doses of 1 mg and 10 mg/kg did not significantly alter the rectal temperature of rabbits pretreated with pargyline except for one rabbit which developed a delayed hyperthermia following the injection of morphine 1 mg/kg.