Vegetal Messenger RNA Localization Directed by a 340-nt RNA Sequence Element in Xenopus Oocytes
- 21 February 1992
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 255 (5047) , 991-994
- https://doi.org/10.1126/science.1546297
Abstract
Contained within a single cell, the fertilized egg, is information that will ultimately specify the entire organism. During early embryonic cleavages, cells acquire distinct fates and their differences in developmental potential might be explained by localization of informational molecules in the egg. The mechanisms by which Vg1 RNA, a maternal mRNA, is translocated to the vegetal pole of Xenopus oocytes may indicate how developmental signals are localized. Data presented here show that a 340-nucleotide localization signal present in the 3′ untranslated region of Vg1 RNA is sufficient to direct RNA localization to the vegetal pole.Keywords
This publication has 23 references indexed in Scilit:
- Nanos is the localized posterior determinant in DrosophilaCell, 1991
- oskar organizes the germ plasm and directs localization of the posterior determinant nanosCell, 1991
- oskar mRNA is localized to the posterior pole of the Drosophila oocyteCell, 1991
- Cis- acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryosNature, 1988
- The maternal mRNA Vg1 is correctly localized following injection into Xenopus oocytesNature, 1988
- Determination of Anteroposterior Polarity in DrosophilaScience, 1987
- A maternal mRNA localized to the vegetal hemisphere in xenopus eggs codes for a growth factor related to TGF-βCell, 1987
- Identification and cloning of localized maternal RNAs from xenopus eggsCell, 1985
- Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursorCell, 1979
- Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animalsJournal of Morphology, 1972