Gastrointestinal stromal tumor of the rectum with activating mutation of c- kit

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Abstract
Nonepithelial malignancies of the large bowel are rare. A new disease entity, gastrointestinal stromal tumors, has attracted attention among primary mesenchymal tumors of the gastrointestinal tract. Here we present a case of spindle-cell sarcoma of the rectum, lacking either smooth muscle cells or neural elements. Immunohistochemical findings and sequencing of the c- kit proto-oncogene diagnosed this tumor as a malignant gastrointestinal stromal tumor of the rectum.