Atypical conditions for quantitative recovery of acepromazine and chlorpromazine from plasma
- 1 May 1981
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 7 (5) , 745-751
- https://doi.org/10.1080/15287398109530016
Abstract
Recoveries of acepromazine and chlorpromazine from equine plasma were examined. Recoveries of both drugs from plasma were poor under theoretically optimal conditions for basic drugs. When a wide range of extraction pH was examined, it was found that more complete recoveries of these drugs from plasma were achieved at pH 5–6. Use of [3 H] chlorpromazine showed that the rate of migration of the drug from an aqueous to a nonpolar environment was much faster at pH 6.0 than at pH 9.2 from both plasma and buffer solutions. Times required for equilibration with agitation were 15 min at pH 6.0, 1 h at pH 9.2, and 2 h at pH 11.0. With these agitation times and pH values, recoveries were more than 95% complete.This publication has 6 references indexed in Scilit:
- Gas-chromatographic analysis for chlorpromazine and some of its metabolites in human serum, with use of a nitrogen detector.Clinical Chemistry, 1979
- The binding of phenothiazines and related compounds to human serum albuminJournal of Pharmacy and Pharmacology, 1976
- Interaction of promazine with bovine serum albumin and hexadecyltrimethylammonium bromide using light absorption and fluorometric techniquesBiochemical Pharmacology, 1974
- Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma by using gas-liquid chromatography with an electron capture detectorAnalytical Chemistry, 1968
- Positive Halogen Compounds. VI. Preparation of Alkoxydimethylsulfonium Salts and their Role in the Kornblum Oxidation. Revision of the Structure for the Olefin-Bromotrinitromethane Adduct.Acta Chemica Scandinavica, 1967