SUPPRESSION OF ACTIVE COLLAGENASE FROM CALCIFIED LAPINE SYNOVIUM BY ARTEPARON
- 1 October 1987
- journal article
- research article
- Vol. 14 (5) , 1013-1017
Abstract
Collagenase has been implicated in the pathogenesis of several arthropathies. Arteparon [glycos-aminoglycan (GAG) polysulfate] is a proteinase inhibitor that is being investigated as a therapeutic agent in osteoarthritis. We found that cutures of calcified lapine synovium release collagenase, one tenth of which is already activated. Normal synovium produces no active collagenase. GAG polysulfate suppresses the amount of active collagenase by one half. GAG polysulfate may interfere with the activation process of collagenase.This publication has 9 references indexed in Scilit:
- THE EFFECT OF GLYCOSAMINOGLYCAN POLYSULFURIC ACID ESTER ON ARTICULAR-CARTILAGE IN EXPERIMENTAL OSTEOARTHRITIS - EFFECTS ON MORPHOLOGICAL VARIABLES OF DISEASE SEVERITY1986
- Degradative enzyme systems in osteoarthritic cartilageJournal of Orthopaedic Research, 1985
- Serine proteinase activation of latent human skin collagenaseBiochemical and Biophysical Research Communications, 1984
- Clearance of 85Sr‐Labeled Calcium Phosphate Crystals from Rabbit JointsArthritis & Rheumatism, 1984
- Crystal populations in human synovial fluid. Identification of Apatite, Octacalcium Phosphate, and Tricalcium PhosphateArthritis & Rheumatism, 1983
- Collagenase and collagenolytic activity in human osteoarthritic cartilageArthritis & Rheumatism, 1983
- Experimental hydroxyapatite synovial and articular cartilage calcification. light and electron microscopic studiesArthritis & Rheumatism, 1982
- Release of Collagenase, Neutral Protease, and Prostaglandins From Cultured Mammalian Synovial Cells by Hydroxyapatite and Calcium Pyrophosphate Dihydrate CrystalsArthritis & Rheumatism, 1981
- Human skin collagenase: isolation of precursor and active forms from both fibroblast and organ culturesBiochemistry, 1977