Effects of Irradiation on Anabolism of Antibody and of Serum Albumin and Globulin

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Abstract
The effect of 500 r whole body X-irradiation on the uptake of S35-L-methionine into antibody, serum globulin, serum albumin and total protein was studied in normal and immunized rabbits. Incorporation into antibody was depressed 30-50% by X-radiation. Incorporation into serum globulin or serum albumin was greatly stimulated by X-radiation. It is felt that these effects are best explained by a primary effect of X-radiation upon desoxyribonucleic acid metabolism.