Abstract
One of the great changes wrought by the widespread use of antibacterial agents has been the radical shift in the ecologic relations among the pathogenic bacteria that are responsible for the most serious and fatal infections. Whereas John Bunyan could properly refer to consumption as "Captain of the Men of Death," this title, according to Osier, was taken over by pneumonia in the first quarter of this century. During the last two decades it has again shifted, at least in hospital populations, first to the staphylococcal diseases1 and more recently to infections caused by gram-negative bacilli.Most of the gram-negative . . .

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