Metabolic Fate of Ubiquinone-7

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Abstract
Absorption, blood level, tissue distribution and elimination were studied on rats after the administration of 14C-labeled ubiquinone-7. Blood radioactivity attained its maximum at 2 hr after the oral dose of a hydrogenated castor oil solution of ubiquinone-7 and gradually declined thereafter, whereas the peak level reached at 6 hr after administration of corn oil solution. Following the intravenous injection, blood radioactivity declined in three phases with half-lives of 2/3, 2 and 22 hr; respectively. Orally ingested ubiquinone-7 was absorbed unchanged exclusively via the lymphatic route. After absorption, the compound was located mainly in liver and excreted into intestinal tract with bile. A part of the radioactivity excreted in bile was resorbed and the remainder excreted in stool together with unabsorbed ubiquinone-7. Thus, 73% of the ingested radioactivity was recovered from urine, feces, expired air and gastrointestinal contents during the first 72 hr, of which the feces accounted for 62%. The fecal excretion was therefore the main route for elimination. All of the data was treated with the simulation technique by analog computer and a metabolic model to fit the observed events was proposed.

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