SYNERGISTIC EFFECTS OF COMBINATION OF CIS-PLATINUM DIAMMINODICHLORIDE AND 2,2'-ANHYDRO-1-BETA-D-ARABINOFURANOSYL-5-FLUOROCYTOSINE IN TRANSPLANTED MOUSE LEUKEMIAS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (11) , 4098-4100
Abstract
Cis-Platinum diamminodichloride was studied in combination with 2,2''-anhydro-1-.beta.-D-arabinofuranosyl-5-fluorocytosine on an every-4-day schedule in various lines of mouse leukemia. This combination is synergistic in leukemias L1210 and P388 and sublines made resistant to 5-fluorouracil or methotrexate. There is no cross-resistance between cis-platinum diamminodichloride and 2,2''-anhydro-1-.beta.-D-arabinofuranosyl-5-fluorocytosine, but the combination is no more effective against lines of leukemia made resistant to cis-platinum diamminodichloride or 2,2''-anhydro-1-.beta.-D-arabinofuranosyl-5-fluorocytosine than either single active compound alone. Since these compounds have no cross-resistance, act by different mechanisms of action and have different limiting toxicity, the combination is now being evaluated clinically.