A Method for Graded Portal Vein Stenosis in Rats: Survival Related to Degree of Stenosis

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Abstract
Using graded portal vein stenosis in rats, a well-defined limit between a high death rate and a high survival rate was found when the diameter of the stenosis was 1.1 mm. A 0.1-mm widening of this threshold stenosis increased the survival rate from 25 to 75%, which is statistically significant. Stenosis with a diameter of 1 mm or less was fatal in nearly 100% of rats weighing approximately 350 g. Total ligature of the portal veins 10 weeks after a 1.2-mm stenosis gave a 100-percent immediate survival.

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