Demonstration of pepsinogen C in human pancreatic islets.
- 30 September 1987
- Vol. 28 (10) , 1208-1214
- https://doi.org/10.1136/gut.28.10.1208
Abstract
Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a raioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.This publication has 20 references indexed in Scilit:
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