Phosphoramides. VII. Phenyl N,N'-Dimethylphosphorodiamidate as a Reagent for Synthesis of 3-Methylthieno[2,3-d]pyrimidin-4(3H)-ones.
- 1 January 1978
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 32b (4) , 303-305
- https://doi.org/10.3891/acta.chem.scand.32b-0303
Abstract
3-Methylthieno[2,3-d]pyrimidin-4(3H)-ones [with biological and pharmacological activity] (4) were obtained in an exothermic reaction by heating phenyl N,N''-dimethylphosphorodiamidate 1 and methyl 2-acylamino-3-thiophenecarboxylates (3) to 250.degree. C. From 3 where R1.tbd.C6H5, R2.tbd.H and R3.tbd.CH3 the expected 4 in 40% yield was obtained, but 6-methyl-2-phenyl-4-methylaminothieno[2,3-d]pyrimidine was also isolated in 45% yield.This publication has 0 references indexed in Scilit: