On the Cause of Vitamin K Deficiency in Male Rats Fed Irradiated Beef and the Production of Vitamin K Deficiency Using an Amino Acid Synthetic Diet

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Abstract
Irradiation of beef, although not producing detectable vitamin K antagonists, reduces the vitamin K activity sufficiently to render deficient those diets that rely solely on irradiated beef for vitamin K. This produces the hemorrhagic condition. Hypoprothrombinemia and hemorrhagic deaths occurred within two weeks in male rats maintained with a completely synthetic amino acid diet when the rats were prevented from practicing coprophagy.

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