Restriction endonuclease maps of the β-like globin gene cluster in the British and Greek forms of HPFH, and for one example ofGγβ+HPFH
- 1 March 1982
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 50 (3) , 415-422
- https://doi.org/10.1111/j.1365-2141.1982.tb01936.x
Abstract
Restriction endonuclease maps of the .beta.-like globin gene cluster for the British form of HPFH [hereditary persistence of fetal Hb] and a case of G.gamma..beta.+ HPFH are reported, and previous reports of the map for the Greek form of HPFH are confirmed and extended. All these conditions belong to a group lacking any substantial deletion or rearrangement of DNA sequence in this gene cluster. The absence of any gross disruption of the structure of this region of the genome, together with evidence that the HPFH genotype is either allelic with, or closely linked to, the .beta.-like globin gene cluster, suggests that the responsible lesions are nearer to being purely regulatory in nature than in forms of HPFH due to substantial deletions. These conditions promise to provide less equivocal evidence about the regulation of .beta.-like globin gene expression than has so far been available.This publication has 23 references indexed in Scilit:
- Major rearrangement in the human β-globin gene clusterNature, 1981
- The primary structure of the human ε-globin geneCell, 1980
- Physical mapping of the globin gene deletion in hereditary persistence of foetal haemoglobin (HPFH)Nucleic Acids Research, 1980
- Molecular cloning and characterization of the human β-like globin gene clusterCell, 1980
- Globin chain synthesis in single erythroid bursts from cord blood: studies on gamma leads to beta and G gamma leads to A gamma switches.Proceedings of the National Academy of Sciences, 1980
- Physical mapping of the globin gene deletion in (δβ)° - thalassaemiaGene, 1979
- Characterisation of deletions which affect the expression of fetal globin genes in manNature, 1979
- The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNACell, 1978
- Hereditary persistence of foetal haemoglobin with β-chain synthesis in cis position (Gγ-β+-HPFH) in a negro familyNature, 1976
- Isolation of High‐Molecular‐Weight DNA from Mammalian CellsEuropean Journal of Biochemistry, 1973