Effect of Early Postnatal Steroid Treatment on Ovarian Function in Prepuberal Rats.

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Abstract
Summary Subcutaneous injection of 10. 100 or 1000 μg of testosterone prop. in a single dose into female rats on the fifth day of life prevented luteinization of the ovaries after 10 days of parabiosis with castrated male rats. Injection of 10 or 100 μg of testosterone propionate on days 5, 7 or 9 of life also prevented luteinization of the ovaries, but animals injected with the same amount of hormone on day 13 had luteinized ovaries. Animals injected with 1 mg of testosterone propionate on day 13 formed no corpora lutea when put in parabiosis at 26 days of age. Animals joined at 36 days of age, however, did form corpora lutea. Animals treated with hormones in the early postpartum period and injected with PMS at 30 days of age did not ovulate. Animals treated with 10 μg of testosterone propionate on day 5 and injected with 16 I.U. of PMS on day 30 did not have corpora lutea at 34 days of age or at 58 days of age.