Contribution of Interleukin 1β and KM Loci to Alopecia areata
- 1 March 1999
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 49 (2) , 85-89
- https://doi.org/10.1159/000022850
Abstract
Alopecia areata is a common skin disease in which proinflammatory cytokines such as IL-1β may play a pathogenic role. In this study, we examined the distribution of genotypes of an IL-1β single base change polymorphism at position +3953 in patients with alopecia areata. The distribution of immunoglobulin κ light chain (KM) genotypes was similarly examined. The data obtained showed that the IL-1β and KM loci act cooperatively to significantly increase susceptibility to alopecia areata.Keywords
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