The Inactivator of the First Component of Human Complement (C1INA)

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Abstract
The mechanism of the inactivation of human CĪ by CĪINA was studied. The reaction of CĪ with C1INA led to the formation of two complexes which were demonstrated as two bands using acrylamide gel electrophoresis. The reaction was accompanied by the decrease of C1r, CĪs and CĪINA activities. One band formed a precipitin line with anti-C1r and anti-CĪINA, and its molecular weight was 220,000. Another band reacted with anti-CTs and anti-C1INA, and its molecular weight was 187,000. Molecular weight of C1r, CĪs and CĪINA were 102,000, 90,000 and 116,000, respectively. From these results, it was concluded that CĪINA formed a 1:1 molecular complex with C1r and with CĪs, leading to the inactivation of these components.

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