Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection
Open Access
- 28 May 2008
- journal article
- Published by Springer Nature in BMC Microbiology
- Vol. 8 (1) , 82
- https://doi.org/10.1186/1471-2180-8-82
Abstract
Decorin-binding proteins (Dbps) A and B of Borrelia burgdorferi, the agent of Lyme disease, are surface-exposed lipoproteins that presumably bind to the extracellular matrix proteoglycan, decorin. B. burgdorferi infects various tissues including the bladder, heart, joints, skin and the central nervous system, and the ability of B. burgdorferi to bind decorin has been hypothesized to be important for this disseminatory pathogenic strategy.Keywords
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