Gene relaxation and aging: Changes in the abundance of rat ventral prostate SGP‐2 (clusterin) and ornithine decarboxylase mRNAs

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Abstract
Sulfated glycoprotein 2 (SGP‐2) mRNA progressively increased in the ventral prostate of the aging rat, reaching, at 24 months, 4‐fold higher than at 3 months. Ornithine decarboxylase (ODC) mRNA peaked at 6 months (4‐fold increase), and at 12 and 24 months was maintained at higher levels than at 3 months. ODC enzymatic activity was enhanced at 6 months to a much smaller extent than its own mRNA, the values at 12 and 24 months dropping to below those at 3 months. Putrescine (Put), spermidine (Spd) and spermine (Sp) concentrations also peaked at 6 months (100% increase for Put, 50% for Sp and Spd). At 24 months, Put and Spd were diminished, and Sp was unchanged with respect to the 3‐month values. Under the same conditions, glyceraldehyde‐3‐phosphate dehydrogenase mRNA did not undergo significant alterations.

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