Oral Administration of Penicillin

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Abstract
THE role of penicillin administered by mouth has been reported on by several investigators,1 2 3 4 5 6 and the conclusion seems warranted that if the drug is given in sufficiently large doses, cures may be expected in susceptible infections. The optimal dose, as well as the necessity of preliminary or concurrent neutralization of the gastric acidity to avoid the inactivating influence of hydrochloric acid in the stomach when penicillin is administered orally, has been the subject of some controversy in the recent literature.2 3 4 , 7 To evaluate the latter point, penicillin blood levels were determined in a control group of over 600 subjects, plain calcium . . .