The relationship between extrapyramidal signs and cognitive function in patients with moderate to severe Alzheimer's disease

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Abstract
We studied the association between extrapyramidal signs (EPS) and neuropsychological performance in 137 patients with moderate to severe Alzheimer's disease (AD) residing in a geographically defined area of inner London, UK. The presence of EPS in AD was associated with a distinct neuropsychological profile, suggestive of the additive effect of frontostriatal degeneration. Yet, there was no significant difference in functional capacity between patients with and without EPS. These findings support the hypothesis that EPS represent a parallel independent pathology superimposed over the classical features of AD, rather than providing a marker for global AD severity.