A Study of the Relation Between the Liver Protein Regeneration Capacity and the Hepatic Necrogenic Activity of Yeast Proteins

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Abstract
Liver protein regeneration and hepatic necrogenic activity of two different types of yeasts (a brewers' and a Torula yeast) have been studied. The results show a close parallelism between these two activities. The Torula yeast was found to be necrogenic at both levels used (9 and 18% protein) and also was incapable of restoring liver protein in the depleted animals. The brewers' yeast behaved similarly at the lower level but at the 18% protein level was found to be non-necrogenic and also capable of restoring maximum liver stores of protein in the depleted animals. Both DL-methionine and L-cystine when fed at a 0.5% level together with the Torula yeast protected all of the animals from developing liver necrosis and also induced a complete regeneration of the liver protein in the depleted animals. When both yeasts were fed together (⅓ brewers' and ⅔ Torula yeasts) full protection against liver necrosis as well as optimum liver protein regeneration was obtained.